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The identified glutathione-related pathways provide potential therapeutic targets for alleviating oxidative stress-induced hippocampal injury in SAE, offering new insights for the clinical management of SAE-related neurological damage

However, downregulation of miR-7 or miR-7 knockdown led to increased NF-B p65 (RELA) and SNAIL protein levels in GC cells, thereby blocking the sensitizing effects of curcumol (136)

In contrast, T2D is characterized by insulin resistance along with relative insufficiency in its secretion due to factors such as obesity, sedentary lifestyle, or genetic predisposition [29]

Reduction in alcohol consumption is a particularly relevant outcome given that GLP-1RAs appear to be most effective for individuals with higher baseline alcohol consumption